Quantitative mass spectrometry analysis reveals similar substrate consensus motif for human Mps1 kinase and Plk1.
BACKGROUND: Members of the Mps1 kinase family play an essential and evolutionarily conserved role in the spindle assembly checkpoint (SAC), a surveillance mechanism that ensures accurate chromosome segregation during mitosis.Human Mps1 (hMps1) is highly phosphorylated during mitosis and many phosphorylation sites have been identified.However, the u